Multi-objective optimization identifies a specific and interpretable COVID-19 host response signatureArticle Published on 2022-12-212023-07-11 Journal: Cell Systems [Category] COVID19(2023년), [키워드] COVID-19 cross-reactivity epigenomics host response signature interpretability optimization plasmablasts robustness transcriptomics viral infection diagnosis. [DOI] 10.1016/j.cels.2022.11.008 PMC 바로가기
Covid-19 and Artificial Intelligence: Genome sequencing, drug development and vaccine discovery코비드-19와 인공 지능: 게놈 시퀀싱, 약물 개발 및 백신 발견Review Published on 2022-02-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] abacavir agility Almitrine applied approval article artificial artificial intelligence Atazanavir bioinformatics Care challenges clinical trial clinical trials collecting data COVID-19 COVID-19 pandemic COVID-19 virus databases deep learning difficulty dolutegravir drug Drug development Drug repurposing drugs efavirenz Genome sequencing genomic genomic sequence genomic sequencing Google Google Scholar growth Health Health care help hydrochloride inhibitor internal and external interpretability machine learning Messenger RNA mesylate Olaparib omicron PARP1 provide recognize Remdesivir Ritonavir Roflumilast SARS- CoV-2 SARS-CoV-2 proteome sequence Sequencing strain structural proteins therapeutic agent therapeutic effect Vaccine Vaccines. variants variants of concern Viral vector vaccines VoC was done [DOI] 10.1016/j.jiph.2022.01.011 PMC 바로가기 [Article Type] Review
Minimizing errors in RT-PCR detection and quantification of SARS-CoV-2 RNA for wastewater surveillance폐수 감시를 위한 SARS-CoV-2 RNA의 RT-PCR 검출 및 정량화 오류 최소화Review Published on 2022-01-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] analyses approaches Chain Reaction communicable diseases Community comparison Concentration controls coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic Critical data interpretation demonstrated effective Efficacy Factor false False negative False positive false-negative False-positive health information identify IMPROVE incidence include Inclusion Inconclusive information initial interpretability Laboratory Measures mitigate pathogen Pathogens PCR polymerase chain reaction positive public health Quality assurance Quality control quantification reliability respiratory retrospective reverse transcription Reverse transcription-polymerase chain reaction RNA extraction RT-PCR RT-PCR assay RT-PCR detection SARS-CoV-2 SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 silver standardized protocol standardized protocols Surveillance virus wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2021.149877 PMC 바로가기 [Article Type] Review
Distinguishing gene flow between malaria parasite populations말라리아 기생충 집단 사이의 유전자 흐름을 구별합니다Research Article Published on 2021-12-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis analyzed approach complementary conditions connectivity death descent disease disease control disperse distinguishing drug-resistant effort epidemiological evaluate gene flow Genetic genetic marker Genetic markers genomic Genomic surveillance geographic location geographic locations Guidance identity implementation implication include Infection information interpretability Interpretation Local malaria malaria control malaria parasite malaria parasites Metrics Migration Multiple National observation observations P. falciparum parasite Population populations public health question sampling sequence similar studies Spread strain Surveillance understanding whole genome sequence [DOI] 10.1371/journal.pgen.1009335 PMC 바로가기 [Article Type] Research Article
A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probeAI 모델과 효소 실험을 통합한 새로운 프레임워크로 SARS-CoV-2 3CL 프로테아제 억제제 및 활성 기반 프로브 식별 촉진Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AIMEE approaches biochemical code conducted coronavirus deep learning domain Drug discovery drugs experiment experiments feature globe highlight IC50 identify inhibitor inhibitors interpretability Interpretation knowledge model interpretation. probe promote protease Protease inhibitor protein-ligand interaction Research SARS-CoV-2 SARS-CoV-2 3CL inhibitors severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown was selected [DOI] 10.1093/bib/bbab301 PMC 바로가기 [Article Type] Article
New Insights Into Drug Repurposing for COVID-19 Using Deep Learning딥 러닝을 사용하여 COVID-19에 대한 약물 용도 변경에 대한 새로운 통찰력Review Published on 2021-11-012022-09-11 Journal: IEEE transactions on neural networks and learning [Category] MERS, 신약개발, 치료제, [키워드] Accessibility Accuracy Activation adopted Algorithms approach approach approaches black box complex complex diseases coronavirus disease Coronavirus disease 2019 COVID-19 Critical deep deep learning develop disease Diseases drug effective effective drugs functions identify improvement Improvements insight interpretability learning New patients Precision referred to Repurposed drug Repurposed drugs repurposing Spread the disease transmitted treat treating COVID-19 Treatment treatment strategy [DOI] 10.1109/TNNLS.2021.3111745 PMC 바로가기 [Article Type] Review
Machine learning automatically detects COVID-19 using chest CTs in a large multicenter cohort기계 학습은 대규모 다기관 코호트에서 흉부 CT를 사용하여 자동으로 COVID-19를 감지합니다.Multicenter Study Published on 2021-11-012022-09-11 Journal: European Radiology [Category] SARS, 치료기술, [키워드] Accuracy Ambiguity applied approach AUC automatically Chest CT classification Classifier Clustering Cohort cohorts control groups COVID-19 COVID-19 cases COVID-19 patients CT scan CT scans deep deep learning detect diagnosis of COVID-19 diagnostic Diagnostic accuracy differentiation distribution facilitate feature Features Hierarchical ILD IMPROVE interpretability Interstitial lung disease Logistic regression Lung disease machine machine learning classifier machine learning classifiers manifestation Manifestations Metrics Mild MOST multicenter Non-COVID-19 opacity overlap Pathologies pathology Pneumonia pneumonias predominant Probability probability distribution Quantitative Quantitative imaging random retrospective reveal robustness sensitivity specificity tomography Unsupervised clustering Viral pneumonia Viral pneumonia. with COVID-19 [DOI] 10.1007/s00330-021-07937-3 PMC 바로가기 [Article Type] Multicenter Study
COVID-Transformer: Interpretable COVID-19 Detection Using Vision Transformer for HealthcareCOVID-Transformer: 의료용 Vision Transformer를 사용한 해석 가능한 COVID-19 감지Article Published on 2021-10-212022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술, [키워드] Accuracy addition affected approach AUC binary classification can be used Chest chest X-ray Chest X-ray image Chest X-ray images chest X-rays collected data country COVID-19 COVID-19 disease COVID-19 patients Critical Data science data set data sets deep learning detection Diagnosis domain grad-CAM healthcare Healthcare industry increase in interpretability knowledge lack limitation Lungs Metrics MONITOR pandemic Patient Pneumonia progression radiologist Radiologists remained scarcity shown Spread the disease time-consuming transfer learning transformer vision vision transformer X-ray [DOI] 10.3390/ijerph182111086 PMC 바로가기 [Article Type] Article
Reliable and Interpretable Mortality Prediction With Strong Foresight in COVID-19 Patients: An International Study From China and GermanyArtificial Intelligence Published on 2021-09-032022-10-31 Journal: Frontiers in Artificial Intelligence [Category] COVID-19, [키워드] Accuracy Admission Analysis applied approach association AUC build C-reactive protein China clinical feature Clinical features Cohort cohorts collected COVID-19 COVID-19 patient COVID-19 patients demonstrated Diseases FIVE foresight Germany hospital independent Infection International interpretability lactate dehydrogenase lymphocyte Mortality mortality prediction model neutrophil count Patient patients with COVID-19 performed prediction Predictive predictive power progression reliability resource resulting robust Strong Treatment Würzburg cohort Wuhan Wuhan cohort α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/frai.2021.672050 PMC 바로가기 [Article Type] Artificial Intelligence
Direct detection of SARS-CoV-2 antisense and sense genomic RNA in human saliva by semi-autonomous fluorescence in situ hybridization: A proxy for contagiousness?반자동 형광에서 인간 타액에서 SARS-COV-2 안티센스 및 감각 게놈 RNA의 직접 검출 : 현장 하이브리드 화 : 전염성을위한 대리?Research Article Published on 2021-08-172022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition All participants antisense applied Cell collected contagiousness cytological described diagnostic Direct DNA Fluorescence genomic genomic RNA healthy human saliva In situ hybridization information interpretability matrix Mild moderate Moderate COVID-19 Participants pathogen transmission pilot study positive presenting probe probes provide Saliva saliva samples SARS-CoV-2 SARS-CoV-2 RNA sense Symptoms test results tested the cells the healthy Validity vector Viral Viral load viral replication virus Visualization [DOI] 10.1371/journal.pone.0256378 PMC 바로가기 [Article Type] Research Article